Table 9.
Constituents of PDC drugs
| PDC drug name | Payload | Linker | Peptide |
|---|---|---|---|
| ANG1005 | Paclitaxel | Succinic acid | Angiopep-2 |
| CBP-1008 | MMAE | Amide | CB-20BK |
| CBP-1018 | MMAE | Amide | LDC10B |
| BT-1718 | DM1 | Disulfide | MT1-MMP binder |
| BT-5528 | MMAE | Amide | Nectin-4 binder |
| G-202 | Thapsigargin | Amide | DγEγEγEγE |
| PEN-221 | DM-1 | Disulfide | fCYwKTCC (2,7 SS) |
| tTF–NGR | tTF | Amide | GNGRAHA |
| TH1904 | Doxorubicin | Succinic acid | TH19P01 |
| TH1902 | Doxorubicin | Succinic acid | TH19P01 |
| SOR-C13 | MMAE | Amide | Folic acid |
| Melflufen | Alkylating agents | Enzymatically cleaved linker | – |
| Paclitaxel with Poliglumex | Paclitaxel | Ester | Poliglumex |
| Thapsigargin with Tetrapeptide | Thapsigargin | Ester | Tetrapeptide |
| Maytansinoid with Bicyclic peptide | Maytansinoid | Disulfide | Bicyclic peptide |
| Doxorubicin-Tetrapeptide | Doxorubicin | Amide | Tetrapeptide |
| EP-100 | CLIP71 | Amino bond | LHRH |
| [18F]AlF-NOTA-octreotide | 18F | NOTA | Octreotide |
| [18F]Fluciclatide | 18F | PEG | RGD |
| [18F]RGD-K5 | 18F | NOTA | Cyclo(RGDfK) |
| 68 Ga-NODAGA-E[cyclo(RGDyK)]2 | 68 Ga | NODAGA | E[cyclo(RGDyK)]2 |
| 68 Ga-NOTA-BBN-RGD | 68 Ga | NOTA | Cyclo(RGDyK)和BBN |
| TH1902 | Docetaxel | Succinic acid | TH19P02 |
MMAE monomethyl auristatin E