Table 4. Risk factors of mortality.
| Univariate | Age- & sex-adjusted | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Lab data | ||||||
| Creatinine | 1.09 | [0.91–1.30] | 0.340 | 1.07 | [0.89–1.29] | 0.467 |
| Hemoglobin | 0.96 | [0.87–1.06] | 0.439 | 0.92 | [0.83–1.03] | 0.137 |
| CRP | 1.03 | [1.01–1.06] | 0.012* | 1.03 | [1.01–1.06] | 0.013* |
| Platelet | 1.00 | [1.00–1.00] | 0.253 | 1.00 | [1.00–1.00] | 0.184 |
| WBC | 1.00 | [1.00–1.00] | 0.041* | 1.00 | [1.00–1.00] | 0.056 |
| Total bilirubin | 0.98 | [0.85–1.13] | 0.809 | 0.98 | [0.85–1.13] | 0.762 |
| Albumin | 0.78 | [0.51–1.20] | 0.260 | 0.80 | [0.50–1.26] | 0.334 |
| Galactomannan test | ||||||
| Blood-First | 1.05 | [0.90–1.23] | 0.506 | 1.08 | [0.91–1.27] | 0.371 |
| Blood-Max | 1.16 | [1.05–1.27] | 0.003** | 1.15 | [1.04–1.27] | 0.005** |
| BAL-First | 1.17 | [1.04–1.31] | 0.011* | 1.25 | [1.09–1.44] | 0.002** |
| BAL-Max | 1.19 | [1.06–1.33] | 0.003** | 1.27 | [1.11–1.46] | 0.001** |
| Comorbidity | ||||||
| COPD | 1.24 | [0.64–2.42] | 0.529 | 0.97 | [0.48–1.96] | 0.930 |
| Asthma | 0.51 | [0.22–1.19] | 0.119 | 0.54 | [0.23–1.26] | 0.154 |
| Liver cirrhosis | 0.78 | [0.19–3.19] | 0.731 | 0.71 | [0.17–2.93] | 0.633 |
| DM | 0.75 | [0.40–1.40] | 0.363 | 0.67 | [0.36–1.25] | 0.210 |
| Hematological disease | 0.90 | [0.56–1.43] | 0.642 | 1.03 | [0.63–1.67] | 0.905 |
| Solid organ malignancy | 1.38 | [0.78–2.46] | 0.269 | 1.18 | [0.65–2.13] | 0.593 |
| Liver or kidney transplant | 0.37 | [0.09–1.51] | 0.166 | 0.27 | [0.07–1.14] | 0.074 |
| IPA groups | ||||||
| Possible IPA | Reference | Reference | ||||
| Probable IPA | 1.05 | [0.62–1.78] | 0.850 | 1.07 | [0.63–1.81] | 0.801 |
| Proven IPA | 0.52 | [0.18–1.48] | 0.217 | 0.42 | [0.15–1.23] | 0.114 |
| Putative IPA | 2.68 | [1.35–5.30] | 0.005** | 2.58 | [1.28–5.23] | 0.008** |
Notes:
Cox proportional hazard regression.
*
p < 0.05.
**
p < 0.01.
CRP, C-reactive protein; WBC, white blood cell; BAL, bronchial alveolar lavage; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; IPA, invasive pulmonary aspergillosis.