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. 2024 Mar 2;30(3):e14636. doi: 10.1111/cns.14636

FIGURE 3.

FIGURE 3

Overexpressing FTO suppresses FYN expression via the m6A modification of FYN. (A) RM2Target analysis of the binding relationship between FTO and FYN; (B, C) Western blot evaluation of FTO and FYN expression in cerebral I/R models; (D, E) Me‐RIP detection of FYN m6A modification levels; (F, G) PAR‐CLIP measurement of FTO binding to FYN mRNA; (H) Detection of stability of FYN mRNA using actinomycin D treatment. *p < 0.05 versus the sham or control group, # p < 0.05 versus the MCAO/R + oe‐NC or OGD/R + oe‐NC group. These values were measurement data and presented as mean ± standard deviation. One‐way ANOVA or Kruskal–Wallis test was adopted for data comparisons among multiple groups. N = 5 in animal experiments; cell experiments were conducted three times.