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. Author manuscript; available in PMC: 2024 Mar 2.
Published in final edited form as: Cell Rep. 2023 Dec 29;43(1):113622. doi: 10.1016/j.celrep.2023.113622

Figure 1. Dissecting cell-type-specific contributions to neurodegeneration in ataxia-telangiectasia using single-nucleus RNA sequencing of postmortem brain and patient iPSC-derived cultures.

Figure 1.

(A) Schematic overview of single-nucleus RNA sequencing (snRNA-seq) experimental design and computational analyses.

(B) Schematic overview of ataxia-telangiectasia (A-T) patient and control human iPSC-derived experimental design. n represents the number of independent culture wells. MG, microglia; PC, Purkinje cells; GC, granule cells; iMGL, iPSC-derived microglia; iN, iPSC-derived neurons.