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. Author manuscript; available in PMC: 2024 Mar 2.
Published in final edited form as: Cell Rep. 2023 Dec 29;43(1):113622. doi: 10.1016/j.celrep.2023.113622

Figure 2. Cell types resolved in A-T and control human cerebellum by snRNA-seq.

Figure 2.

(A) Uniform manifold approximation and projection (UMAP) dimensionality reduction plot of major cell types identified in A-T and control human cerebellum, downsampled to 10,000 cells for each condition.

(B) Top five marker genes for each major cell type in control cerebellum. Heatmap depicts centered and scaled log-normalized expression values.

(C) Cell-type proportions in A-T and control cerebellum.

(D) Relative abundance of cell types in A-T versus control cerebellum, shown as the posterior distribution of log2(proportion in A-T/proportion in control) with 89% credible interval. Red bars highlight credible intervals that do not overlap 0. Bolded cell-type labels indicate a significant difference in relative abundance.