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. Author manuscript; available in PMC: 2024 Mar 2.
Published in final edited form as: Cell Rep. 2023 Dec 29;43(1):113622. doi: 10.1016/j.celrep.2023.113622

Figure 3. Gene Ontology (GO) analysis of differentially expressed genes in A-T cerebellum.

Figure 3.

(A–C) Select enriched GO biological processes among DEGs in (A) A-T Purkinje neurons, (B) granule neurons, and (C) microglia. Select genes in each pathway and their log2 fold changes (A-T/control) shown in the heatmap. Bar plot shows significance of pathway enrichment among upregulated genes (red) and downregulated genes (blue).

(D) CD11B immunostaining of postmortem cerebellar cortex from A-T and control. WM, white matter; GL, granule layer; ML, molecular layer. Quantification of CD11B+ cells across cerebellar cortex layers in A-T and control. Error bar represents 95% confidence interval. ****Bonferroni-adjusted p < 1e—04, Mann-Whitney U test. Scale bar, 50 μm.