Table 2.
Multiple regression assessing interactions between age and sex on MCA pulsatility in 396 adults
|
Model 1
|
Model 2
|
Model 3
|
||||
|---|---|---|---|---|---|---|
| B (95% CI) | β | B (95% CI) | β | B (95% CI) | β | |
| Age | −0.01 (−0.02, −0.01) | −1.71** | −0.01 (−0.02, −0.01) | −1.63** | −0.01 (−0.01, −0.004) | −1.07** |
| Age2 | 1.50 (0.90, 2.10) | 1.61** | 1.50 (0.90, 2.10) | 1.60** | 1.20 (0.60, 1.70) | 1.24** |
| Female sex | −0.12 (−0.19, −0.05) | −0.49** | −0.12 (−0.19, −0.05) | −0.48** | 0.001 (−0.07, 0.07) | 0.00 |
| Sex × age | 0.003 (0.001, 0.004) | 0.51** | 0.002 (0.001, 0.004) | 0.49* | 0.00 (−0.001, 0.002) | 0.02 |
| BMI | −0.001 (−0.004, 0.002) | −0.05 | 0.001 (−0.002, 0.003) | 0.02 | ||
| MAP | −0.001 (−0.002, 0.00) | −0.08 | −0.004 (−0.005, −0.002) | −0.29** | ||
| CCA PP | 0.006 (0.005, 0.007) | 0.50** | ||||
| Adjusted R2 | 0.074 | 0.074 | 0.264 | |||
| Adjusted ΔR2 | 0.074 | 0.00 | 0.19 | |||
| F statistic | 8.88 | 5.00 | 16.76 | |||
Males, n = 189; females, n = 207. Age2 unstandardized beta is reported as ×10−4. Antihypertensive therapy and statin therapy use included as covariates in models 2 and 3 but are not reported. B, unstandardized beta weight; MCA, middle cerebral artery; CI, confidence interval; BMI, body mass index; MAP, mean arterial pressure; CCA PP, common carotid artery pulse pressure. Significant predictor at *P < 0.05 and **P ≤ 0.001.