Figure 1.

Overview of cardiovascular cell senescence. Cells originating from the heart and vascular tissue are prone to enduring nonlethal stressors, particularly during disease or aging, leading to the development of a phenotypic state referred to as cellular senescence. Consequently, senescent cardiomyocytes, vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and fibroblasts have all been implicated in the pathogenesis of diverse cardiovascular-related pathologies. The detrimental consequences of senescent cells in cardiovascular diseases (CVDs) and aging have sparked considerable interest in the development of senescence-targeting drugs aimed at inhibiting or selectively eliminating these cells. Images were created with a licensed version of BioRender.com and Photoshop.