Figure 2.

Transcriptomic approaches have emerged as powerful tools for elucidating the characteristics of senescent cardiovascular cells. The advent of RNA-sequencing technologies has significantly advanced our ability to comprehensively profile the transcriptomes of cardiac and vascular tissues in healthy, diseased, and aged states. By integrating transcriptomic data obtained from various methods such as bulk, single-cell, and spatial RNA-sequencing, we can construct highly intricate signatures specific to senescent cardiovascular cells, enabling their identification and localization in vivo. Moreover, leveraging the gene expression profiles of these cells, we can devise therapeutic strategies to combat the presence of senescent cells in cardiovascular diseases (CVDs) and aging. These transcriptomic strategies offer valuable insights into the molecular mechanisms underlying senescence-associated pathologies, facilitating the development of targeted interventions for CVDs and age-related cardiovascular complications. Images were created with a licensed version of BioRender.com and Photoshop.