Figure 3.

Innovative proteomic technologies for targeting and quantifying cellular senescence in the cardiovascular system. Investigation of cardiovascular senescence through proteomic analysis of in vivo models, such as human and mouse, as well as isolated cells and tissues enables novel insights into proteomic changes during cardiovascular aging. Protein alterations at different levels of analysis, including bulk proteomics, cell-surface proteomics, and post-translational modifications (PTMs), as well as the assessment of circulating proteomics from secreted factors in blood plasma or serum promote the discovery of senescence-associated molecular signatures. By combining the outcomes of proteomics strategies, we can enhance the identification of senescent cell signatures within cardiovascular tissue, leading to the discovery of potential biomarker candidates and novel therapeutic targets. Images were created with a licensed version of BioRender.com and Photoshop.