Table 1. Univariate analysis of baseline demographics and covariates between cohorts with and without complication following O-CTR.

N: number; SD: Standard deviation; IQR: Interquartile range; CTS-6: Carpal tunnel syndrome-6 test; EDX: Electrodiagnostic testing; PHQ-2: Patient Health Questionnaire-2; PRA: Patient-reported allergies; O-CTR: Open carpal tunnel release

Variable	No complication	With complication	p-value
Number (n) of patients	199	51
Age, mean (SD)	54.6 (13.9)	56.2 (11.9)	0.44
Sex			0.10
Female	137 (68.8%)	41 (80.4%)
Male	62 (31.2%)	10 (19.6%)
BMI, median (IQR)	30.9 (27.4, 35.8)	29.9 (25.8, 35.9)	0.47
Laterality			0.09
Left	93 (46.7%)	17 (33.3%)
Right	106 (53.3%)	34 (66.7%)
Hand dominance			0.46
Left	25 (12.6%)	4 (7.8%)
Right	174 (87.4%)	47 (92.2%)
Tobacco status			0.39
Smoker	152 (76.4%)	36 (70.6%)
Non-smoker	47 (23.6%)	15 (29.4%)
CTS-6, median (IQR)	16.5 (13.0, 16.5)	16.5 (16.5, 16.5)	0.30
Patients with EDX, n (%)	157 (78.9%)	36 (70.6%)	0.21
EDX components, mean (SD)
Sensory latency (ms)	4.1 (3.0, 7.7)	3.9 (3.0, 5.1)	0.35
Motor latency (ms)	5.1 (4.6, 6.5)	4.9 (3.8, 7.2)	0.60
Sensory conduction velocity (m/s)	35.8 (31.0, 42.0)	45.3 (30.8, 48.5)	0.047
Pathologic electric activity present, n (%)	78 (84.8%)	14 (15.2%)	0.30
Charlson Comorbidity Index, median (IQR)	1.0 (0.0, 3.0)	2.0 (1.0, 3.0)	0.29
PHQ-2, n (%)			<0.01
Less than 3	178 (89.4%)	38 (74.5%)
3 to 6	21 (10.6%)	13 (25.5%)
Number of PRAs, n (%)			<0.01
Less than 2	122 (61.3%)	21 (41.2%)
2 to 5	63 (31.7%)	16 (31.4%)
5 or more	14 (7.0%)	14 (27.5%)
PRAs by category, n (%)			0.54
Environmental	38 (12.1%)	19 (11.8%)
Food-based	24 (7.7%)	16 (9.9%)
Antibiotic	87 (27.8%)	41 (25.5%)
Pain meds	63 (20.1%)	41 (25.5%)
Other	101 (32.3%)	44 (27.3%)
PRA by reaction, n (%)			0.41
No. of anaphylactic reactions	19 (6.1%)	13 (8.1%)
No. of minor/local reactions	294 (93.9%)	148 (91.9%)
No. OT visits, median (IQR)	0.0 (0.0, 0.0)	0.0 (0.0, 1.0)	<0.01
Follow-up duration (weeks), median (IQR)	2.3 (2.0, 7.3)	8.1 (6.1, 17.1)	<0.01