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. 2024 Mar 2;70(3):538–550. doi: 10.1093/clinchem/hvad221

Table 1.

Participant characteristics by lumbar puncture protocol. Samples were categorized by cognitive diagnosis at the nearest visit. Some participants provided samples more than once, some in more than one tube type, and some at more than one stage of cognitive impairment.

Variable pull/frozen/Sarstedt 0.5 mL screw top pull/frozen/Fisher 1.5 mL microcentrifuge pull/frozen/Fisher 2.0 mL cryovial pull/frozen/Matrix 1.0 mL cryotube drip/fresh/Sarstedt 2.5 mL non-stick drip/frozen/Sarstedt 2.5 mL non-stick
Number of participants 249 393 36 201 43 95
Number of observations 252 501 36 223 43 95
Number of measurements 290 543 60 225 43 95
Diagnosis, unimpaired, n (%) 222 (89%) 322 (82%) 32 (89%) 168 (84%) 37 (86%) 82 (86%)
Diagnosis, MCI, n (%) 17 (7%) 37 (9%) 4 (11%) 18 (9%) 3 (7%) 7 (7%)
Diagnosis, dementia, n (%) 3 (1%) 27 (7%) 10 (5%)
Diagnosis, missing, n (%) 7 (3%) 7 (2%) 5 (2%) 3 (7%) 6 (6%)
Age at lumbar puncture, mean (SD) 65.33 (7.58) 64.86 (8.58) 63.65 (8.98) 64.20 (8.48) 67.97 (7.29) 65.33 (8.30)
Number of cognitive visits, mean (SD) 4.95 (2.27) 5.59 (2.14) 5.53 (1.92) 5.28 (2.71) 5.47 (2.33) 4.79 (2.66)