Table 3. Diagnostic performance of UFR- and IVUS-derived MLA to identify FFR ≤ 0.80.
| UFR ≤ 0.80 | MLA ≤ 4.5 mm2 | MLA ≤ 6.0 mm2 | |||||||
| Estimate (95% CI) |
Estimate (95% CI) |
Difference (95% CI)* |
P-value | Estimate (95% CI) |
Difference (95% CI)* |
P-value | |||
| +LR: positive likelihood ratio; −LR: negative likelihood ratio; MLA: minimal lumen area; NPV: negative predictive value; PPV: positive predictive value; UFR: ultrasound flow ratio. | |||||||||
| Accuracy (%), n = 41 | 82.9 (70.2–95.7) | 58.5 (42.2–74.8) | 24.4 (5.7–43.1) | 0.01 | 80.5 (67.1–93.8) | 2.4 (–14.4 to 19.3) | 0.78 | ||
| Sensitivity (%), n = 29 | 93.1 (82.2–100.0) | 48.3 (28.4–68.2) | 44.8 (24.2–65.4) | < 0.0001 | 86.2 (71.9–100.0) | 6.9 (–10.2 to 24.0) | 0.43 | ||
| Specificity (%), n = 12 | 58.3 (26.3–90.4) | 83.3 (58.1–100.0) | –25.0 (–58.4 to 8.4) | 0.14 | 66.7 (35.8–97.5) | –8.3 (–43.7 to 27.1) | 0.64 | ||
| PPV (%) | 84.4 (70.2–98.5) n = 32 |
87.5 (68.2–100.0) n = 16 |
–3.1 (–28.3 to 22.1) | 0.88 | 82.8 (67.3–98.2) n = 29 |
–1.8 (–22.9 to 19.2) | 0.87 | ||
| NPV (%) | 77.8 (45.1–100.0) n = 9 |
40.0 (21.1–61.3) n = 25 |
37.8 (–3.0 to 78.6) | 0.08 | 66.7 (34.9–90.1) n = 12 |
11.1 (–36.7 to 58.9) | 0.94 | ||
| +LR, n = 41 | 2.23 (1.14–4.40) | 2.90 (0.77–10.8) | - | - | 2.59 (1.15–5.83) | / | / | ||
| - LR, n = 41 | 0.12 (0.03–0.49) | 0.62 (0.40–0.96) | - | - | 0.21 (0.08–0.56) | / | / | ||