Table 3. Predictors for 2-year POCE following the PCI procedure based on the developmental dataset.
| Covariables | Univariate analysis | Multivariate analysis | |||||
| RR | 95% CI | P-value | RR | 95% CI | P-value | ||
| Adjusted covariates included age, sex, hypertension, diabetes, smoking history, CHD family history, previous MI, previous PCI, and previous stroke. ACEF: age, creatinine, and ejection fraction; CHD: coronary heart disease; LVEF: left ventricular ejection fraction; PCI: percutaneous coronary intervention; POCE: patient-oriented composite endpoint; QFR: quantitative flow ratio; RR: relative risk. | |||||||
| Age | 1.031 | (1.015, 1.048) | < 0.001 | 1.024 | (1.004, 1.043) | 0.017 | |
| Sex | 0.740 | (0.507, 1.081) | 0.119 | 0.626 | (0.425, 0.923) | 0.018 | |
| Body mass index | 0.941 | (0.896, 0.988) | 0.014 | 0.955 | (0.905,1.008) | 0.093 | |
| Creatinine | 1.002 | (1.001, 1.004) | 0.003 | 1.001 | (1.000, 1.004) | 0.021 | |
| Creatinine clearance | 0.991 | (0.986, 0.997) | 0.002 | 0.999 | (0.994,1.005) | 0.791 | |
| Hypertension | 1.410 | (0.994, 2.001) | 0.054 | 1.292 | (0.901, 1.854) | 0.164 | |
| Hyperlipidemia | 1.129 | (0.807, 1.579) | 0.479 | 1.217 | (0.863, 1.715) | 0.263 | |
| Diabetes | 1.355 | (0.951, 1.931) | 0.093 | 1.380 | (0.966, 1.974) | 0.077 | |
| Insulin used | 1.229 | (0.681, 2.217) | 0.493 | 0.945 | (0.485, 1.841) | 0.868 | |
| Smoking history | 1.205 | (0.873, 1.664) | 0.257 | 1.398 | (1.002, 1.949) | 0.048 | |
| Family history of CHD | 0.746 | (0.349, 1.594) | 0.449 | 0.861 | (0.400, 1.850) | 0.700 | |
| Previous myocardial infarction | 1.321 | (0.897, 1.944) | 0.158 | 1.389 | (0.941, 2.049) | 0.098 | |
| Previous PCI | 0.803 | (0.463, 1.392) | 0.434 | 0.754 | (0.434, 1.311) | 0.317 | |
| Previous stroke | 1.957 | (1.304, 2.936) | 0.001 | 1.730 | (1.145, 2.613) | 0.009 | |
| Peripheral vascular disease | 1.580 | (0.740, 3.374) | 0.238 | 1.203 | (0.555, 2.610) | 0.639 | |
| Left ventricular ejection fraction | 0.790 | (0.772, 0.808) | 0.028 | 0.793 | (0.776, 0.811) | 0.045 | |
| LVEF < 40% | 1.210 | (0.496, 2.951) | 0.675 | 0.983 | (0.401, 2.412) | 0.971 | |
| Average baseline QFR | 0.144 | (0.058, 0.361) | < 0.001 | 0.167 | (0.067, 0.416) | < 0.001 | |
| Average post-PCI QFR | 0.081 | (0.025, 0.265) | < 0.001 | 0.099 | (0.030, 0.329) | < 0.001 | |
| Lowest post-PCI QFR | 0.064 | (0.023, 0.182) | < 0.001 | 0.085 | (0.030, 0.243) | < 0.001 | |
| Post-PCI QFR ≤ 0.92 | 2.737 | (1.974, 3.794) | < 0.001 | 2.621 | (1.889, 3.635) | < 0.001 | |