Table 1. Causal association between transferrin saturation and left ventricular parameters.

Exposure 1	Outcome	N	Methods	β (95% CI)	P	P for intercept	P for Q statistics
IVW: inverse variance weighting; LVEDV: left ventricular end-diastolic volume; LVEF: left ventricular ejection fraction; LVESV: left ventricular end-systolic volume; LVMVR: left ventricular mass-to-end-diastolic volume ratio; LVM: left ventricular mass; TSAT: transferrin saturation.
TSAT	LVMVR	20	IVW(re)	-0.137 (-0.209, -0.064)	0.000	0.775	0.581
		20	IVW(fe)	-0.137 (-0.209, -0.064)	0.000
		20	MR Egger	-0.150 (-0.265, -0.034)	0.020
		20	Weighted median	-0.173 (-0.277, -0.068)	0.001
		20	Maximum likelihood	-0.137 (-0.210, -0.064)	0.000
	LVEDV	20	IVW(re)	0.062 (-0.010, 0.135)	0.092	0.352	0.522
		20	IVW(fe)	0.062 (-0.010, 0.135)	0.092
		20	MR Egger	0.106 (-0.009, 0.221)	0.088
		20	Weighted median	0.099 (0.003, 0.196)	0.043
		20	Maximum likelihood	0.063 (-0.010, 0.136)	0.090
	LVESV	20	IVW(re)	0.078 (0.005, 0.150)	0.035	0.318	0.816
		20	IVW(fe)	0.078 (0.005, 0.150)	0.035
		20	MR Egger	0.125 (0.010, 0.240)	0.048
		20	Weighted median	0.095 (0.001, 0.190)	0.048
		20	Maximum likelihood	0.078 (0.006, 0.151)	0.035
	LVM	20	IVW(re)	-0.055 (-0.127, 0.018)	0.141	0.475	0.500
		20	IVW(fe)	-0.055 (-0.127, 0.018)	0.141
		20	MR Egger	-0.021 (-0.137, 0.094)	0.721
		20	Weighted median	-0.080 (-0.192, 0.033)	0.167
		20	Maximum likelihood	-0.055 (-0.128, 0.018)	0.141
	LVEF	20	IVW(re)	-0.045 (-0.118, 0.028)	0.229	0.389	0.758
		20	IVW(fe)	-0.045 (-0.118, 0.028)	0.229
		20	MR Egger	-0.085 (-0.201, 0.030)	0.166
		20	Weighted median	-0.040 (-0.136, 0.055)	0.407
		20	Maximum likelihood	-0.045 (-0.118, 0.028)	0.229