Table 3. Causal association between total iron binding capacity and left ventricular parameters.

Exposure 3	Outcome	N	Methods	β (95% CI)	P	P for intercept	P for Q statistics
IVW: inverse variance weighting; LVEDV: left ventricular end-diastolic volume; LVEF: left ventricular ejection fraction; LVESV: left ventricular end-systolic volume; LVMVR: left ventricular mass-to-end-diastolic volume ratio; LVM: left ventricular mass.
TIBC	LVMVR	25	IVW(re)	0.102 (0.003, 0.202)	0.044	0.160	0.212
		25	IVW(fe)	0.102 (0.012, 0.192)	0.026
		25	MR Egger	0.201 (0.036, 0.366)	0.025
		25	Weighted median	0.157 (0.028, 0.286)	0.017
		25	Maximum likelihood	0.103 (0.013, 0.194)	0.025
	LVEDV	25	IVW(re)	-0.052 (-0.154, 0.050)	0.320	0.465	0.160
		25	IVW(fe)	-0.052 (-0.142, 0.038)	0.260
		25	MR Egger	-0.105 (-0.279, 0.069)	0.250
		25	Weighted median	-0.110 (-0.237, 0.016)	0.088
		25	Maximum likelihood	-0.052 (-0.143, 0.038)	0.258
	LVESV	11	IVW(re)	-0.105 (-0.251, 0.042)	0.163	0.988	0.059
		11	IVW(fe)	-0.105 (-0.215, 0.006)	0.063
		11	MR Egger	-0.103 (-0.337, 0.130)	0.408
		11	Weighted median	-0.100 (-0.225, 0.029)	0.131
		11	Maximum likelihood	-0.106 (-0.217, 0.005)	0.061
	LVM	25	IVW(re)	0.042 (-0.048, 0.132)	0.360	0.616	0.605
		25	IVW(fe)	0.042 (-0.048, 0.132)	0.360
		25	MR Egger	0.074 (-0.079, 0.227)	0.352
		25	Weighted median	0.080 (-0.044, 0.205)	0.207
		25	Maximum likelihood	0.043 (-0.048, 0.133)	0.356
	LVEF	25	IVW(re)	0.025 (-0.077, 0.127)	0.630	0.570	0.163
		25	IVW(fe)	0.025 (-0.065, 0.116)	0.586
		25	MR Egger	0.067 (-0.109, 0.243)	0.464
		25	Weighted median	0.032 (-0.093, 0.157)	0.617
		25	Maximum likelihood	0.026 (-0.065, 0.116)	0.583