Table 4. Causal association between ferritin and left ventricular parameters.

Exposure 4	Outcome	N	Methods	β (95% CI)	P	P for intercept	P for Q statistics
IVW: inverse variance weighting; LVEDV: left ventricular end-diastolic volume; LVEF: left ventricular ejection fraction; LVESV: left ventricular end-systolic volume; LVMVR: left ventricular mass-to-end-diastolic volume ratio; LVM: left ventricular mass.
Ferritin	LVMVR	52	IVW(re)	-0.014 (-0.120, 0.093)	0.986	0.073	0.124
		52	IVW(fe)	-0.014 (-0.109, 0.082)	0.986
		52	MR Egger	-0.172 (-0.371, 0.027)	0.842
		52	Weighted median	-0.040 (-0.179, 0.100)	0.961
		52	Maximum likelihood	-0.014 (-0.110, 0.083)	0.986
	LVEDV	25	IVW(re)	0.049 (-0.087, 0.185)	0.477	0.519	0.591
		25	IVW(fe)	0.049 (-0.087, 0.185)	0.477
		25	MR Egger	0.118 (-0.128, 0.363)	0.357
		25	Weighted median	0.039 (-0.161, 0.240)	0.700
		25	Maximum likelihood	0.050 (-0.087, 0.187)	0.476
	LVESV	52	IVW(re)	0.078 (-0.021, 0.177)	0.122	0.119	0.347
		52	IVW(fe)	0.078 (-0.018, 0.173)	0.110
		52	MR Egger	0.206 (0.020, 0.392)	0.035
		52	Weighted median	0.071 (-0.078, 0.220)	0.353
		52	Maximum likelihood	0.079 (-0.017, 0.175)	0.108
	LVM	52	IVW(re)	0.102 (-0.003, 0.206)	0.056	0.256	0.165
		52	IVW(fe)	0.102 (0.006, 0.197)	0.037
		52	MR Egger	0.201 (0.002, 0.401)	0.053
		52	Weighted median	0.063 (-0.091, 0.217)	0.420
		52	Maximum likelihood	0.103 (0.006, 0.199)	0.037
	LVEF	52	IVW(re)	-0.012 (-0.115, 0.091)	0.822	0.927	0.208
		52	IVW(fe)	-0.012 (-0.108, 0.084)	0.809
		52	MR Egger	-0.004 (-0.203, 0.196)	0.970
		52	Weighted median	-0.047 (-0.192, 0.098)	0.522
		52	Maximum likelihood	-0.012 (-0.109, 0.085)	0.809