Table 3.

Association between BMI, VFA, SFA, AISI, SII, and overall survival

Characteristic	Model I		Model II		Model III			Model IV		Model V
	HR (95% CI)1	p value	HR (95% CI)1	p value	HR (95% CI)1		p value	HR (95% CI)1	p value	HR (95% CI)1		p value
BMI
Underweight	1.181 (0.356, 3.915)	0.786			1.051 (0.312, 3.537)		0.936	1.390 (0.419, 4.610)	0.590	1.173 (0.353, 3.897)		0.795
Normal	Ref				Ref			Ref		Ref
Overweight	0.836 (0.559, 1.252)	0.385			0.979 (0.647, 1.481)		0.920	0.716 (0.470, 1.090)	0.119	0.831 (0.552, 1.252)		0.376
Obese	0.767 (0.495, 1.190)	0.236			1.103 (0.696, 1.749)		0.676	0.723 (0.465, 1.125)	0.150	0.761 (0.486, 1.192)		0.233
VFA
High	Ref		Ref					Ref		Ref
Low	2.545 (1.785, 3.628)	< 0.001	2.601 (1.792, 3.776)	< 0.001				2.544 (1.783, 3.631)	< 0.001	3.193 (2.151, 4.739)		< 0.001
SFA
High	Ref		Ref		Ref			Ref
Low	1.023 (0.719, 1.455)	0.899	0.969 (0.674, 1.394)	0.867	0.598 (0.403, 0.887)		0.011	1.111 (0.778, 1.587)	0.563
AISI	1.235 (1.085, 1.406)	0.001	1.274 (1.115, 1.456)	< 0.001	1.216 (1.067, 1.386)		0.003			1.242 (1.090, 1.416)		0.001
SII	1.225 (1.060, 1.417)	0.006	1.249 (1.081, 1.444)	0.003	1.177 (1.014, 1.366)		0.032			1.228 (1.062, 1.420)		0.006

Model II was adjusted for covariates plus BMI (underweight/normal/obese/overweight)

Model III was adjusted for covariates plus VFA (high/low)

Model IV was adjusted for covariates plus AISI (continuous) and SII (continuous)

Model V was adjusted for covariates plus SFA (high/low)

¹HR hazard ratio, CI confidence interval, BMI body mass index, VFA visceral fat area, SFA subcutaneous fat area, AISI Aggregate Index of Systemic Inflammation, SII systemic immune- inflammation index

*All models were adjusted for the following covariates: age (continuous), gender (male/female), TMN stage (I/II), sarcopenia (with/ without)