Table 4.

Association between BMI, VFA, SFA, AISI, SII, and progression-free survival

Characteristic	Model I		Model II		Model III			Model IV			Model V
	HR (95% CI)1	p value	HR (95% CI)1	p value	HR (95% CI)1		p value	HR (95% CI)1		p value	HR (95% CI)1		p value
BMI
Underweight	1.087 (0.328, 3.598)	0.891			0.975 (0.290, 3.273)		0.967	1.242 (0.375, 4.107)		0.723	1.137 (0.341, 3.788)		0.834
Normal	Ref				Ref			Ref			Ref
Overweight	0.836 (0.556, 1.257)	0.389			0.981 (0.647, 1.488)		0.930	0.726 (0.475, 1.110)		0.140	0.872 (0.575, 1.322)		0.518
Obese	0.728 (0.465, 1.139)	0.164			1.052 (0.654, 1.693)		0.835	0.695 (0.443, 1.090)		0.113	0.768 (0.484, 1.217)		0.261
VFA
High	Ref		Ref					Ref			Ref
Low	2.545 (1.785, 3.628)	< 0.001	2.601 (1.792, 3.776)	< 0.001				2.535 (1.777, 3.619)		< 0.001	3.193 (2.151, 4.739)		< 0.001
SFA
High	Ref		Ref		Ref			Ref
Low	1.272 (0.890, 1.819)	0.186	1.241 (0.856, 1.801)	0.254	0.811 (0.542, 1.213)		0.307	1.385 (0.965, 1.988)		0.077
AISI	1.211 (1.064, 1.378)	0.004	1.239 (1.086, 1.414)	0.001	1.190 (1.044, 1.356)		0.009				1.227 (1.078, 1.396)		0.002
SII	1.170 (1.008, 1.357)	0.039	1.187 (1.024, 1.375)	0.023	1.123 (0.963, 1.308)		0.139				1.176 (1.015, 1.362)		0.031

Model II was adjusted for covariates plus BMI (Underweight / Normal / Obese / Overweight)

Model III was adjusted for covariates plus VFA (high/low)

Model IV was adjusted for covariates plus AISI (continuous) and SII (continuous)

Model V was adjusted for covariates plus SFA (High / Low)

¹HR hazard ratio, CI confidence interval, BMI body mass index, VFA visceral fat area, SFA subcutaneous fat area, AISI Aggregate Index of Systemic Inflammation, SII systemic immune- inflammation index

*All models were adjusted for the following covariates: age (continuous), gender (male/female), TMN stage (I/II), Sarcopenia (with/without)