Table 2.
Pathological characteristics
| Total N= 1152 | PDAC N= 1047 | I-IPMN N = 105 | P value | |
|---|---|---|---|---|
|
Staging Ia/Ib IIa/IIb III IV |
533 (46) 437 (38) 167 (14) 15 (1) |
481 (46) 396 (38) 157 (15) 13 (1) |
52 (50) 41 (39) 10 (10) 2 (2) |
0.458 |
|
T stage Complete NAT response T 1 a,b,c T 2 T 3 T 4 |
65 (6) 269 (23) 482 (42) 308 (27) 28 (2) |
64 (6) 232 (22) 450 (43) 273 (26) 28 (3) |
1 (1) 37 (35) 32 (30) 35 (33) 0 |
< 0.001 |
|
N stage N 0 N 1 N 2 |
667 (58) 332 (29) 153 (13) |
601 (57) 304 (29) 142 (14) |
66 (63) 28 (27) 11 (10) |
0.506 |
| Metastatic at surgery | 15 (1) | 13 (1) | 2 (2) | 0.568 |
| Harvested lymph nodes, mean ± SD | 21.4 ± 9.9 | 21.5 ± 9.8 | 20.2 ± 10.8 | 0.190 |
|
Pathologic grade Undetermined G1 G2 G3 G4 |
77 (7) 68 (6) 617 (54) 375 (33) 11 (1) |
75 (7) 47 (4) 571 (55) 340 (32) 11 (1) |
2 (2) 21 (20) 46 (44) 35 (33) 0 |
< 0.001 |
|
IPMN duct involvement Branch duct Main duct/Mixed |
– | – |
– 20 (19) 85 (81) |
|
| Perineural invasion | 503 (44) | 473 (45) | 30 (29) | 0.001 |
| Lymphovascular invasion | 176 (15) | 165 (16) | 11 (10) | 0.151 |
| R1 | 108 (9) | 103 (10) | 5 (5) | 0.089 |
Bold values indicate statistically significant results (p < 0.05)
SD = standard deviation, NAT = neoadjuvant therapy, PDAC = pancreatic ductal adenocarcinoma, I-IPMN = invasive intraductal mucinous cystic neoplasm