Table 3.

Advantages and disadvantages of cell types used for microvascular network formation

Cell type	Advantages	Disadvantages	Ref.
Primary cells	Easy to obtain, closest to the body’s cells	Acquiring and isolating primary cells is a costly and time-consuming process, complicated by the heterogeneity and inter-donor variability	[122]
Cell lines	Standardization, scale, low cost	The genome of the cell has been modified, resulting in the absence of certain traits present in the primary cell	[119, 128]
iPSCs	Provides tissue specific cell types	Multiple differentiation is necessary to acquire target cells	[42, 132]