Skip to main content
. 2024 Mar 2;15:1947. doi: 10.1038/s41467-024-46180-4

Fig. 6. GREB1 is required for P4-responses but not E2-responses in receptive endometrium.

Fig. 6

a Experimental protocol for hormonal induction of uterine receptivity in ovariectomized mice. b Representative images of uteri from WT and Greb1 KO mice from indicated groups, stained for phospho-Histone H3. G, glandular epithelia; LE luminal epithelia, S stroma. c The graph displays the percentage of phospho-Histone H3 positive endometrial stromal cells in WT and Greb1 KO mice from the E2 + P4 group. Red arrow, PH3-positive cells; black arrow, PH3-negative cells; n = 5 mice per group. Paired, two-tailed, t-test. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 and ns, non-significant Relative mRNA expression of Greb1 and Pgr (d) and indicated PR target genes (e), in uteri from WT and Greb1 KO mice in the indicated treatment groups, n = 5 mice per group. Analyzed by one-way ANOVA with Tukey’s multiple comparisons post-test. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ns, non-significant.