Table 2.

All of the heterogeneity and horizontal pleiotropy test of the MR analysis.

Exposure	Outcome	Methods	Heterogeneity		Horizontal pleiotropy
			Q	P values	MR-Egger intercept	P values
Appearance	SSc	MR Egger	0.780	0.993	0.102	0.813
		Inverse variance weighted	0.841	0.997
AT	SSc	MR Egger	NA	NA	NA	NA
		Inverse variance weighted	1.854	0.173
GD	SSc	MR Egger	11.854	0.158	-0.074	0.237
		Inverse variance weighted	14.271	0.113
Hypothyroidism	SSc	MR Egger	74.652	0.981	0.001	0.927
		Inverse variance weighted	74.661	0.984
SSc	AT	MR Egger	NA	NA	NA	NA
		Inverse variance weighted	13.011	0.0003
SSc	GD	MR Egger	NA	NA	NA	NA
		Inverse variance weighted	16.506	4.85e−05
SSc	Hypothyroidism	MR Egger	NA	NA	NA	NA
		Inverse variance weighted	83.690	5.79e−20

SSc: systemic sclerosis; AT: autoimmune thyroiditis; GD: graves’ disease.