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. 2024 Mar 3;14:5201. doi: 10.1038/s41598-024-55865-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sequence coverage plots showing selected detected structural variants related to drug resistance and lineages (regions of difference, RD) identified in Oxford Nanopore Technologies (ONT) and Illumina (Illumina) platforms. Coverage is indicated by blue mounds with isolate labels on the side. (A) RD105 deletion confirmed in isolate S15 (lineage 2.2.1). All samples from lineage 2 contained this deletion; (B) RD152 deletion confirmed in isolate S24. While it does not span the entire deletion, a consistent pattern has been observed across all samples from lineage 2, suggesting shared deletion characteristics; (C) a deletion in the ppe50 gene in isolate S66 that was present across all lineage 1 strains; (D) an entire deletion of the eis gene in isolate S27, potentially linked to drug resistance.