Table 2.
Drug resistance mutations identified in the 59 M. tuberculosis isolates.
| Drug | Gene | Mutation** | Our study N | Our study % | Other Thailand % | Global % |
|---|---|---|---|---|---|---|
| (/59) | (n = 1456)*** | (n = 50k)**** | ||||
| Isoniazid | fabG1 | -15C>T | 5 | 8.4 | 6.1 | 25.0 |
| Isoniazid | katG | Ser315Thr | 9 | 15.3 | 56.9 | 78.6 |
| Isoniazid | katG | 1002_1003dupGA | 1 | 1.7 | 0.1 | 0.0 |
| Rifampicin | rpoB | Ser450Trp | 2 | 3.4 | 0.8 | 1.1 |
| Rifampicin | rpoB | His445Tyr | 2 | 3.4 | 7.5 | 3.3 |
| Rifampicin | rpoB | Ser450Leu | 3 | 5.1 | 35.6 | 57.7 |
| Ethionamide | ethA | Thr232Ala | 5 | 8.4 | 0.5 | 0.0 |
| Ethionamide | fabG1 | -15C>T | 5 | 8.4 | 6.1 | 25.0 |
| Ethambutol | embA | -16C>T | 1 | 1.7 | 0.8 | 2.4 |
| Ethambutol | embB | Arg507Lys | 1 | 1.7 | 0.1 | 0.0 |
| Ethambutol | embB | Met306Leu | 1 | 1.7 | 1.0 | 1.2 |
| Pyrazinamide | pncA | Ser104Arg | 5 | 8.4 | 0.7 | 0.5 |
| Pyrazinamide | pncA | Thr142Lys | 1 | 1.7 | 0.2 | 0.1 |
| Ciprofloxacin | gyrA | Asp94Gly | 1 | 1.7 | 5.1 | 11.7 |
| Ciprofloxacin | gyrB | Asp494Ala | 1 | 1.7 | 0.6 | 0.0 |
| Fluoroquinolones | gyrA | Asp94Gly | 1 | 1.7 | 5.1 | 11.7 |
| Fluoroquinolones | gyrB | Asp494Ala | 1 | 1.7 | 0.6 | 0.0 |
| PAS | thyX | -16C>T | 1 | 1.7 | 2.5 | 2.4 |
| Streptomycin | gid | Glu92* | 1 | 1.7 | 0.1 | 0.1 |
| Streptomycin | gid | 351delG | 1 | 1.7 | 1.0 | 1.8 |
| Streptomycin | gid | 351dupG | 1 | 1.7 | 0.3 | 0.4 |
| Streptomycin | rpsL | Lys43Arg | 3 | 5.1 | 37.6 | 38.9 |
| Streptomycin | rpsL | Lys88Arg | 2 | 3.4 | 3.6 | 9.9 |
| Streptomycin | rrs | 514A>C | 2 | 3 | 1.6 | 7.3 |
| Streptomycin | rrs | 517C>T | 1 | 1.7 | 0.8 | 4.6 |