Table 3.
Sensitivity, Specificity, Positive predictive value and Negative predictive value of combined expression of S100, SOX10, MMG, and DOG1 in differentiating Secretory carcinoma from other salivary gland lesions
| S. no | Study | Total no. of Test/control Cases | Varying patterns of immunoreactivity | TP | FN | FP | TN | Sensitivity | Specificity | Positive Predictive value (%) | Negative Predictive value (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S100 ± SOX10 + DOG1-MMG + | S100 + SOX10 + DOG1 + MMG + | S100 + SOX10-DOG1-MMG + | S100 + SOX10 ± DOG1 ± MMG- | |||||||||||
| 1 | Urano M/2015 Japan | 10/8 | 9 | 0 | 0 | 1 | 9 | 1 | 4 | 4 | 90.00% | 50.00% | 69.23% | 80.00% |
| 2 | Woo WY/2017 Australia | 1/1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 75.00% | 50.00% | 100.00% | 0.00% |
| 3 | Baghai F/2017 Iran | 0/37 | 7 | 3 | 0 | 0 | 0 | 0 | 10 | 27 | 50.00% | 72.40% | 0.00% | 100.00% |
| 4 | Baneckova M/2018 Czech Republic | 0/17 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 15 | 50.00% | 86.10% | 0.00% | 88.24% |
| 5 | Rooper LM/2018 USA | 1/0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 75.00% | 50.00% | 100.00% | 0.00% |
| 6 | Skalova A/2018 Czech Republic | 30/0 | 30 | 0 | 0 | 0 | 30 | 0 | 0 | 0 | 98.40% | 50.00% | 100.00% | 0.00% |
| 7 | Karabachev A/2020 USA | 1/0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 75.00% | 50.00% | 100.00% | 0.00% |
| 8 | Shibata E/2020 Japan | 1/0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 75.00% | 50.00% | 100.00% | 0.00% |
| 9 | Wu B/2020 Australia | 1/0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 75.00% | 50.00% | 100.00% | 0.00% |
| 10 | Li YH/2021 New Zealand | 2/0 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 83.30% | 50.00% | 100.00% | 0.00% |
| 11 | Uy TC/2022 Philippiness | 1/0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 75.00% | 50.00% | 100.00% | 0.00% |
| 12 | Kallarakkal TG/2022 Malaysia | 0/1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 50.00% | 75.00% | 0.00% | 100.00% |
| 13 | Alkaabba F/2022 USA | 1/0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 75.00% | 50.00% | 100.00% | 0.00% |
| 14 | Wiles AB/2022 USA | 3/0 | 1 | 0 | 6 | 0 | 3 | 0 | 0 | 0 | 87.50% | 50.00% | 100.00% | 0.00% |
FP False positive; FN False negative; MMG Mammaglobin; TP True positive; TN True negative