Table 3.
Comparison of p53 immunoexpression between normal group with pathological grades of differentiation
| Parameters | Groups | P-value* | |||
|---|---|---|---|---|---|
| Normal (n = 40) |
OSCC (n = 30) | ||||
| WDSCC (n = 20) |
MDSCC (n = 20) |
PDSCC (n = 5) | |||
| Percentage positive cells (p53) | |||||
| Mean ± SD | 16.00 ± 5.20 | 40.33 ± 25.98 | 50.50 ± 27.32 | 52.00 ± 30.20 | 0.995(NS) |
| Staining Intensity (p53) | |||||
| No positivity found | 6 (15%) | 5 (25%) | 8 (40%) | 2 (40%) | < 0.0001 (HS) |
| Positivity only at 40x | 4 (10%) | 2 (10%) | 1 (5%) | 0 | |
| Positivity obvious at 10x not at 4x | 29 (67.5%) | 1 (5%) | 1 (5%) | 0 | |
| Positivity obvious at 4x | 1 (2.5%) | 12 (60%) | 10 (50%) | 3 (60%) | |
| Staining Index (p53) |
< 0.0001 (HS) |
||||
|
Negative (Absent) |
6 (15%) | 5 (25%) | 8 (40%) | 2 (40%) | |
| Low | 33 (82.5%) | 3 (15%) | 2 (10%) | 0 | |
| Medium | 1 (2.5%) | 4 (20%) | 2 (10%) | 1 (20%) | |
| High | 0 | 8 (40%) | 8 (40%) | 2 (40%) | |
| Mean ± SD | 1.87 ± 0.34 | 5.27 ± 3.15 | 6 ± 3.07 | 6 ± 3 | |