Table 4. ROC curve analysis of MRV in identifying anemia diagnosed by the combination of RHE and RPI.

Variables	AUC	95%CI		p-value	Optimal cutoff values	Sensitivity	Specificity	Youden index
		Lower	Upper
Males
MRV	0.829	0.762	0.895	<0.001	100.95	1.00	0.68	0.68
MCV	0.795	0.721	0.869	<0.001	90.65	0.90	0.59	0.49
MCH	0.782	0.700	0.865	<0.001	31.85	0.65	0.79	0.44
RET#	0.782	0.704	0.859	<0.001	0.07	0.88	0.59	0.47
HGB	0.726	0.640	0.812	<0.001	109.50	0.95	0.40	0.35
HCT	0.716	0.627	0.804	<0.001	33.80	0.88	0.49	0.36
RBC	0.627	0.531	0.724	0.019	3.68	0.85	0.43	0.28
MCHC	0.594	0.489	0.700	0.084	347.50	0.38	0.80	0.18
RDW-CV	0.384	0.284	0.485	0.034	12.10	1.00	0.02	0.02
Females
MRV	0.884	0.831	0.936	<0.001	98.35	1.00	0.73	0.73
MCH	0.811	0.742	0.880	<0.001	30.75	0.77	0.76	0.53
RET#	0.786	0.714	0.859	<0.001	0.06	0.96	0.50	0.46
MCV	0.768	0.693	0.842	<0.001	85.75	0.98	0.44	0.42
MCHC	0.721	0.636	0.805	<0.001	341.50	0.65	0.72	0.37
HGB	0.697	0.612	0.782	<0.001	109.50	0.79	0.53	0.32
HCT	0.668	0.578	0.757	0.001	32.65	0.79	0.52	0.31
RBC	0.498	0.401	0.595	0.971	2.89	1.00	0.07	0.07
RDW-CV	0.343	0.255	0.431	0.002	12.15	0.98	0.06	0.03

Notes.

MRV

mean reticulocyte volume

RPI

reticulocyte production index

RHE

reticulocyte hemoglobin content

RBC

red blood cell

HCT

hematocrit

MCV

mean corpuscular volume

MCH

mean corpuscular hemoglobin

MCHC

mean corpuscular hemoglobin concentration

RDW-CV

red cell distribution width-coefficient of variation

RET#

eticulocyte count

ROC

receiver operating characteristic

AUC

area under curve

CI

confidence interval

P values were calculated by ROC curve analysis.