Table 2.

FABP dysregulation in cancer

Cancer type	FABP(s)	Association	Reference
Intestine	FABP1	FABP1 deletion protects against tumorigenesis in a small intestinal adenoma mouse model	32
		Enhanced FABP1 expression in small intestine epithelial cells promotes tumorigenesis	1
	FABP4	High expression has been shown in colon cancer tissue	173
	FABP5	FABP5 upregulation promotes proliferation in colon cancer cells	153
	FABP7	High expression correlates with cell proliferation in colon cancer tissues	117
Gastrointestinal stromal cancer	FABP3	High FABP3 protein expression	22
Gastric	FABP5	FABP5 knockdown decreases proliferation	201
Esophageal	FABP3	High FABP3 protein expression	29
Liver	FABP1	High FABP1 protein expression in hepatocellular carcinoma tissues	93
	FABP4	High expression in liver cancer stem cells	193
		High expression in hepatic stellate cells in hepatocellular carcinoma	26
Non-small cell lung cancer	FABP3	High FABP3 mRNA and protein expression in NSCLC tumor tissues	171
	FABP5	Knockdown decreases proliferation of lung adenocarcinoma cells	52
	FABP7	FABP7 is prometastatic in NSCLC cell lines	9
Breast	FABP2	Transcriptional modulation by hormones and microenvironment in culture cells	113
	FABP3	Transcriptional modulation by hormones and microenvironment in culture cells	113
		High protein expression in tumor tissues and adipose microenvironment	110
	FABP4	High protein expression in tumor tissues and adipose microenvironment	110
	FABP5	High protein expression in tumor tissues and adipose microenvironment	110
	FABP7	High expression of FABP7 in human triple-negative breast cancer tissue	108
Uterine sarcoma	FABP3	High FABP3 expression in tumor tissues	30
Ovary	FABP4	High expression in ovarian cancer tissues	56
Melanoma	FABP8	High FABP8 protein expression	59
	FABP7	FABP7 knockdown decreased proliferation in melanoma cell lines	176
Squamous cell carcinoma	FABP7	FABP7 levels reduced in patient samples	168
Renal	FABP5	FABP5 silencing inhibited proliferation of renal clear cell carcinoma cells	114
Prostate cancer	FABP5	Knockdown of FABP5 decreases proliferation in vitro	132
	FABP9	High FABP9 protein expression in cultured cells	3
	FABP12	FABP12 in metastatic prostate cancer	106
Bladder	FABP6	FABP6 knockdown decreases cell cycle progression and migration in vitro	105
Glioma	FABP4	High expression in glioblastoma tissue and cell lines	111
	FABP5	Suppression of FABP5 decreases proliferation in vitro	180
	FABP6	Knockdown of FABP6 in glioblastoma cells reduced tumor cell invasion	137
	FABP7	Overexpression of FABP7 increases proliferation of glioblastoma cells	81
		Overexpression of FABP7 protective in glioma cell line	74
Neuroblastoma	FABP4	High expression in tumor-associated macrophages in neuroblastoma	123
Leukemia	FABP4	High expression in acute myeloid leukemia cells	195
Lymphoma	FABP7	Ectopic expression in patients with large B cell lymphoma	112

Abbreviations: FABP, fatty acid–binding protein; NSCLC, non-small cell lung cancer.