. 2023 Sep 17;15(1):e1816. doi: 10.1002/wrna.1816

TABLE 2.

Cell‐cycle CDKs in S. cerevisiae.

Cyclin‐dependent kinase	Binding partner	Roles in cell cycle	Roles in transcription	Selected additional roles
Cdc28	Cln1‐3, Clb1‐6	Orchestrates mitosis and determines its timing; executes ‘START’ control in G1 and the initiation of DNA replication (Enserink & Kolodner, 2010; Hartwell et al., 1973; Mendenhall & Hodge, 1998)	Phosphorylates factors in cell‐cycle transcriptional programs (Archambault et al., 2004; R. J. Cho, Huang, et al., 2001; Cosma et al., 2001; Darieva et al., 2003; De Bruin et al., 2004; Enserink & Chymkowitch, 2022; Jans et al., 1995; Kõivomägi et al., 2011; Moll et al., 1991; O'Conalláin et al., 1999; Pic‐Taylor et al., 2004; Reynolds et al., 2003; Ubersax et al., 2003; Wittenberg & Reed, 2005) CTD kinase (T4, S5) (Chymkowitch & Enserink, 2013; Kõivomägi et al., 2021; Nemec et al., 2019) Recruits the proteasome to the promoter regions of certain genes (Morris et al., 2003; Yu et al., 2005). Maintains transcription of highly expressed housekeeping genes (e.g., PMA1) (Chymkowitch et al., 2012) Increases transcription through activating NuA4 leading to increased Lys14 acetylation on Htz1 (Fiedler et al., 2009) Recruits the proteasome to promoter regions of specific genes (Morris et al., 2003; V. P. C. C. Yu et al., 2005)	Implicated in bud morphogenesis (Enserink & Kolodner, 2010; Lew & Reed, 1993) Antagonizes pheromone signaling in G1 (Enserink & Kolodner, 2010) Governs genome stability and DNA repair pathways (Enserink & Kolodner, 2010)

Cyclin‐dependent kinase

Binding partner

Roles in cell cycle

Roles in transcription

Selected additional roles

Cdc28

Cln1‐3, Clb1‐6

Orchestrates mitosis and determines its timing; executes ‘START’ control in G1 and the initiation of DNA replication (Enserink & Kolodner, 2010; Hartwell et al., 1973; Mendenhall & Hodge, 1998)

Phosphorylates factors in cell‐cycle transcriptional programs (Archambault et al., 2004; R. J. Cho, Huang, et al., 2001; Cosma et al., 2001; Darieva et al., 2003; De Bruin et al., 2004; Enserink & Chymkowitch, 2022; Jans et al., 1995; Kõivomägi et al., 2011; Moll et al., 1991; O'Conalláin et al., 1999; Pic‐Taylor et al., 2004; Reynolds et al., 2003; Ubersax et al., 2003; Wittenberg & Reed, 2005)

CTD kinase (T4, S5) (Chymkowitch & Enserink, 2013; Kõivomägi et al., 2021; Nemec et al., 2019)

Recruits the proteasome to the promoter regions of certain genes (Morris et al., 2003; Yu et al., 2005). Maintains transcription of highly expressed housekeeping genes (e.g., PMA1) (Chymkowitch et al., 2012)

Increases transcription through activating NuA4 leading to increased Lys14 acetylation on Htz1 (Fiedler et al., 2009)

Recruits the proteasome to promoter regions of specific genes (Morris et al., 2003; V. P. C. C. Yu et al., 2005)

Implicated in bud morphogenesis (Enserink & Kolodner, 2010; Lew & Reed, 1993)

Antagonizes pheromone signaling in G1 (Enserink & Kolodner, 2010)

Governs genome stability and DNA repair pathways (Enserink & Kolodner, 2010)