TABLE 1.

Brief overview of compounds under investigation for inhibition of hyaluronidase‐1.

Name	IC50
Ascorbyl palmitate	4.2 ± 0.13 (SagHL) 46	Potent hyaluronidase inhibitor in vitro. Esterified form of vitamin C. 46 Globally approved antioxidant food additive (E304)
Chebulanin	132 μM (EcH1) 49	Anti‐inflammatory and anti‐arthritic agent that inhibits NF‐κB and MAPK signalling pathway activation 50 , 51
Chicoric acid	171 μM (EcH1) 52	Dicaffeoyl ester with properties that include anti‐inflammatory and anti‐aging properties and glucose and lipid metabolism regulation 53
Glycyrrhizic acid	177 μM (EcH1) 54	Known anti‐allergic, anti‐viral and anti‐inflammatory, anti‐lipidaemic and anti‐hyperglycaemic properties. 55 FDA‐approved food additive
Testosterone propionate	124 ± 1.1 μM (EcH1) 52	Slow‐release anabolic steroid. Shown to be neuroprotective in animal models of Parkinson's disease 56

Abbreviations: EcH1, Escherichia coli F470 cells expressing Hyal1; SagHL, Streptococcus agalactiae hyaluronate lyase.