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VP40 sequence and structure revels two potential PI(4,5)P2 binding sites. A: Consensus sequence of Ebola VP40 strains highlighting several lysine residues in the 220 and 269 amino acid regions of the protein and positioned at the surface of the C-terminal domain. B: VP40 dimer structure (PDB ID: 4LDB with missing Lys loop residues modeled in) with region 1 lysine residues colored in blue, and region 2 lysine residues colored in green.
