Table 5.
Comparison of the population with isolated low von Willebrand factor ristocetin cofactor vs type 1 von Willebrand disease.
| Characteristic | Isolated low VWF:RCo n = 33 | Type 1 VWD n = 75 | P value |
|---|---|---|---|
| Demographics | |||
| Age | 15.8 (11.0-17.9) | 15.8 (7.7-17.4) | .90a |
| Female sex | 25 (61.0%) | 56 (74.7%) | .12b |
| ISTH BAT BS | 4 (3-5) | 4 (3-5) | .26a |
| Procedure information | |||
| No. of procedures | 41 | 120 | |
| Bleeding events | 2 | 6 | |
| Bleeding frequency | 4.9% | 5.0% | .84b |
| Surgical type | |||
| Major | 16 (39.0%) | 43 (35.8%) | |
| Minor | 17 (41.5%) | 49 (40.8%) | |
| Dental | 8 (19.5%) | 28 (23.3%) | .86b |
| Prophylaxis plan | |||
| Antifibrinolytic only | 35 (85.4) | 93 (77.5) | |
| Antifibrinolytic + DDAVP | 4 (9.8) | 13 (10.8) | |
| Antifibrinolytic + VWF concentrate | 0 | 12 (10.0) | |
| DDAVP only | 0 | 1 (0.8) | |
| None | 2 (4.9) | 1 (0.8) | .07b |
BAT, bleeding assessment tool; BS, bleeding score; DDAVP, desmopressin; ISTH, International Society on Thrombosis and Haemostasis; VWD, von Willebrand disease; VWF, von Willebrand factor; RCo, ristocetin cofactor.
b
Mann–Whitney U-test.
a
Fisher’s exact test.