Figure 2.

A and B: Scatterplots of PVI (A) versus Index60 and PVI versus DPTRS (B) demonstrate no correlation between PVI and either of the metabolic measures. C: In contrast, Index60 and DPTRS, which are both derived from metabolic testing, are significantly correlated. Shaded area displays 95% CI for each linear fit. D: ROC curves for stratifying individuals who experienced progression to stage 3 T1D versus nonprogressors based on measurement at study entry. ROC AUC for logistic regression incorporating PVI and DPTRS exceeds any single measure alone (P < 0.05). E: Time-dependent ROC analysis demonstrates that PVI or combination of T1D stage, DPTRS, and PVI predicts individuals who will develop stage 3 T1D years before progression.