Table 2.

Anti-inflammatory activity of caffeine, theobromine, and (+)-catechin

Anti-inflammatory activity		Caffeine	(+)- Catechin	Theobromine
Immunomodulator	P.a	0.561	–	0.539
	P.i	0.007	–	0.009
Immunosuppressant	P.a	0.450	0.348	0.558
	P.i	0.053	0.086	0.034
Interleukin 8 antagonist	P.a	0.213	–	0.359
	P.i	0.009	–	0.005
Tumor necrosis factor antagonist	P.a	0.309	–	0.241
	P.i	0.015	–	0.027
Interleukin 5 antagonist	P.a	–	–	0.106
	P.i	–	–	0.036
Interleukin 1 antagonist	P.a	0.168	–	0.126
	P.i	0.050	–	0.083
Mucositis treatment	P.a	–	0.375	0.246
	P.i	–	0.123	0.243
TNF expression inhibitor	P.a	0.488	0.517	0.415
	P.i	0.032	0.026	0.052
Cyclic AMP phosphodiesterase inhibitor	P.a	0.943	0.266	0.858
	P.i	0.003	0.134	0.003