Table 3.

Anticarcinogenic activity of caffeine, theobromine, and (+)-catechin

Anticarcinogenic activity		Caffeine	(+)- Catechin	Theobromine
Regulator of nucleotide metabolism	P.a	0.745	0.329	0.782
	P.i	0.009	0.111	0.007
Leukopoiesis stimulant	P.a	0.684	0.272	0.762
	P.i	0.008	0.217	0.004
Testosterone 17-beta dehydrogenase (NADP +) inhibitor	P.a	0.608	0.716	0.695
	P.i	0.087	0.050	0.057
Radiosensitizer	P.a	0.722	0.253	0.634
	P.i	0.004	0.177	0.009
Chemoprotective	P.a	0.438	0.546	0.391
	P.i	0.018	0.008	0.024
Antineoplastic antimetabolite	P.a	0.233	–	0.374
	P.i	0.028	–	0.019
Antineoplastic potentiator	P.a	–	–	0.276
	P.i	–	–	0.037
Anticarcinogenic	P.a	0.204	0.795	0.245
	P.i	0.115	0.005	0.086
Antineoplastic (solid tumors)	P.a	0.224	–	0.263
	P.i	0.176	–	0.124
MAP kinase 1 inhibitor	P.a	–	–	0.180
	P.i	–	–	0.059
Treatment of proliferative diseases	P.a	–	0.681	0.199
	P.i	–	0.007	0.096
Alpha agonist interferon	P.a	0.229	–	0.223
	P.i	0.118	–	0.124
Antimetastatic	P.a	–	0.290	0.225
	P.i	–	0.086	0.130
BCR-ABL kinase inhibitor	P.a	0.139	–	0.140
	P.i	0.047	–	0.046
MAP kinase 4 inhibitor	P.a	0.214	0.377	0.228
	P.i	0.163	0.008	0.137
VEGFR2 expression inhibitor	P.a	0.009	–	0.008
	P.i	0.005	–	0.007