Table 2.
Subcortical structural volume analysis investigating the interaction between the study group and measures of sleep disturbance.
Dependent variable: volume of subcortical structure | Interaction term | |||||
---|---|---|---|---|---|---|
Study group × ESS | Study group × ISI | |||||
β | Unadjusted value of p | FDR adjusted value of p | β | Unadjusted value of p | FDR adjusted value of p | |
Left thalamus | 0.14 | 0.45 | 0.84 | 0.21 | 0.13 | 0.68 |
Left caudate | −0.26 | 0.19 | 0.68 | 0.02 | 0.91 | 0.91 |
Left putamen | 0.21 | 0.35 | 0.75 | 0.55* | 0.001 | 0.02 |
Left pallidum | 0.05 | 0.79 | 0.91 | 0.06 | 0.69 | 0.89 |
Left hippocampus | −0.08 | 0.70 | 0.89 | −0.39 | 0.009 | 0.09 |
Left amygdala | 0.13 | 0.52 | 0.85 | −0.19 | 0.22 | 0.68 |
Left accumbens | 0.03 | 0.88 | 0.91 | 0.04 | 0.78 | 0.91 |
Right thalamus | 0.09 | 0.66 | 0.89 | 0.16 | 0.30 | 0.71 |
Right caudate | −0.14 | 0.50 | 0.85 | 0.02 | 0.88 | 0.91 |
Right putamen | 0.26 | 0.22 | 0.68 | 0.51* | 0.001 | 0.02 |
Right pallidum | 0.10 | 0.63 | 0.89 | 0.19 | 0.26 | 0.68 |
Right hippocampus | −0.31 | 0.15 | 0.68 | −0.24 | 0.15 | 0.68 |
Right amygdala | 0.22 | 0.27 | 0.68 | −0.11 | 0.44 | 0.84 |
Right accumbens | −0.11 | 0.63 | 0.89 | −0.04 | 0.83 | 0.91 |
Independent variables: Age, sex, estimated total intracranial volume, study group, sleep disturbance measure (i.e., ESS and ISI), study group × sleep disturbance measure (interaction term). Study groups are encoded as follows: Shift workers: 1; non-shift workers: 0. *FDR adjusted value of p < 0.05. ESS, Epworth Sleepiness Scale; ISI, Insomnia Severity Index; FDR, False Discovery Rate.