Table 2.

Results of Mendelian randomization analysis.

Outcome	Data source	Method	n SNPs	OR	Lower limit of 95%CI	Upper limit of 95%CI	P-value
Non-small cell lung cancer, adenocarcinoma	FinnGen databases	MR Egger	20	0.995	0.94	1.06	0.890204
		Weighted median	20	0.992	0.95	1.03	0.746656
		Inverse variance weighted	20	1.007	0.97	1.05	0.692271
		Simple mode	20	0.987	0.92	1.06	0.734049
		Weighted mode	20	0.977	0.92	1.04	0.427744
Non-small cell lung cancer, adenocarcinoma	The IEU Open GWAS	MR Egger	12	0.991	0.94	1.05	0.791947
		Weighted median	12	0.985	0.96	1.02	0.34669
		Inverse variance weighted	12	0.98	0.95	1.02	0.233971
		Simple mode	12	1.01	0.95	1.06	0.776474
		Weighted mode	12	1.008	0.96	1.06	0.793913
Non-small cell lung cancer, squamous	FinnGen databases	MR Egger	20	1.06	0.98	1.15	0.154438
		Weighted median	20	1.04	0.98	1.1	0.24092
		Inverse variance weighted	20	1.02	0.98	1.06	0.322191
		Simple mode	20	0.994	0.92	1.07	0.898038
		Weighted mode	20	1.05	0.97	1.14	0.238938
Non-small cell lung cancer, squamous	The IEU Open GWAS	MR Egger	12	1.05	1.01	1.1	0.058696
		Weighted median	12	1.007	0.98	1.03	0.65404
		Inverse variance weighted	12	1.001	0.98	1.02	0.920803
		Simple mode	12	1.01	0.96	1.06	0.688296
		Weighted mode	12	1.009	0.96	1.05	0.698975
Small cell lung cancer	FinnGen databases	MR Egger	20	1.11	0.99	1.24	0.094093
		Weighted median	20	1.04	0.96	1.13	0.344022
		Inverse variance weighted	20	1.05	0.99	1.11	0.130286
		Simple mode	20	1.04	0.92	1.18	0.528023
		Weighted mode	20	1.04	0.94	1.15	0.458009