Table 1.2.

Gender-Specific Microbiome Profile Alterations in Subjects with Major Depression.

Diversity	Alpha Diversity				Beta Diversity
	MDD vs HC	MDD vs HC		MDD	MDD vs HC
	Female	Male		Female vs Male	Female	Male
Chen et al., 2018 (32)	NS	NS		NS	*	*
Li et al., 2022 (33)	NS	NS		---	*	*
Chen et al 2021 (34)	NS	NS		N/A	NS (16SrRNA) *(SMG)	N/A
Hu et al., 2023 (35)	*↓	*↓		---	---	---

MDD, Major Depressive Disorder; HC, Healthy Controls; NS, No significant difference; *Significant difference; ---, not reported; *↓Significantly decreased; N/A, not applicable; 16s, 16S rRNA gene sequencing; SMG, shotgun metagenomic sequencing.