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. 2024 Feb 19;14:1354636. doi: 10.3389/fcimb.2024.1354636

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Copyright © 2024 da Silva Lira Filho, Lafleur, Marcet-Palacios and Olivier

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene Ontology analysis of total proteins detected in fractions of Leishmania major-derived extracellular vesicles display notable variations. Proteins detected by LC-MS/MS in 2K, 10K, and 100K fractions of Leishmania major-derived EVs were annotated using PANTHER (pantherdb.org) gene ontology analysis (GO) according to (A) Biological Processes, (B) Molecular Function, and (C) Cellular Component (Level 3 – membrane-bound organelle). When classified according to biological processes and molecular functions, no significant changes are apparent in terms of percentage of the total classified proteins. Most significant differences are regarding the cellular component, suggesting that the cellular origins of the EV fractions are (A) mitochondrial, (B) nuclear and (C) vacuolar/endosomal.