TABLE 2.
Cell cycle analysis of HIV-1-infected and uninfected CD4+ T cellsa
| Time (days) p.i.b | HIV-1 status | % of cells in:
|
|||
|---|---|---|---|---|---|
| G1 | G2/M | S | Apoptosis | ||
| 0 | − | 71 | 11 | 17 | 1 |
| 4 | − | 82 | 6.4 | 6.2 | 5.2 |
| + | 81 | 7.2 | 6.0 | 5.4 | |
| 7 | − | 70.8 | 4.4 | 2.3 | 22.9 |
| + | 66.6 | 4.8 | 2.6 | 26 | |
| 10 | − | 66.4 | 4.2 | 2.6 | 26.8 |
| + | 59 | 3.5 | 2.0 | 35.5 | |
Cell cycle analyses based on DNA content per cell were performed as described in Materials and Methods; 20,000 cells were analyzed. Data shown are representative of three separate experiments from individual normal donors.
Days postinfection (p.i.) of PHA-activated CD4+ T cells purified, activated, and infected as described in Materials and Methods. Day 0, time of infection, 3 days after PHA activation.