Figure 3.

CIS gene signature in CIS and papillary tumors with validation at individual gene level

(A) CIS-specific gene signature composed of 46 genes (up- and downregulated) were identified. Unsupervised clustering shows clear segregation of CIS samples from other samples.

(B) AUC curve showing performance of CIS-specific gene signature average score in predicting CIS samples from an independent cohort (GSE3167).

(C) volcano plot showing fold change and p value for individual gene validation from the signature in GSE3167 dataset. Genes passing both Log2 fold change cutoff of 0.5 and Wilcoxon rank-sum test p value cutoff of 0.05 are shown as red dots.