Figure 4.

Mutational landscape of CIS and papillary tumor samples (moderate and high impact SNVs and indels)

Columns correspond to unique samples. Groups of columns correspond to all analyzed samples from a single patient. Top: the number of the four mutation types in every sample. Middle: oncoplot showing the four mutation types in selected genes, sorted by mutation frequency across patients. Frequencies of patients with mutations in the given gene are indicated to the left. Bars to the right indicate the numbers of the different mutation types within each gene across the samples in the cohort. Bottom: clinical and sample information. BCG outcome: high-grade disease within two years after BCG treatment or progression to muscle-invasive bladder cancer (MIBC) progression to MIBC. BCG Timing: sample timing in relation to BCG treatment.