Table 7.

Influence of MeOH/MeOD on urea and carbamate reactivity.

Entry	Substrate/ solvent	Additive	kobs∙105/s−1
1	1a/CH2Cl21a/CD2Cl2	n/a	51 ± 1 37 ± 1
2	1a/CH2Cl2	0.18 M MeOD	70 ± 2
3	1a/CH2Cl2	0.88 M MeOD	130 ± 10
4	1a/CH2Cl2	1.9 M MeOD	81 ± 1
5	1a/CD2Cl2	0.18 M MeOH	97 ± 3
6	1a/CD2Cl2	0.88 M MeOH	381 ± 6
7	1a/CD2Cl2	1.9 M MeOH	539 ± 30
8	1b/CH2Cl2	0.18 M CD3OD	0.54 ± 0.02
9	1b/CH2Cl2	0.88 M CD3OD	2.15 ± 0.01
10	1b/CH2Cl2	1.9 M CD3OD	1.76 ± 0.02
11	1b/CH2Cl2	0.18 M MeOH	0.97 ± 0.02
12	1b/CH2Cl2	0.88 M MeOH	6.11 ± 0.09
13	1b/CH2Cl2	1.9 M MeOH	6.9 ± 0.2