Table 2. Apparent steady-state kinetic constants of mevalonate kinases with mevalonate (MVA) as the substrate (n = 4).

Organism	K m, MVA/ATP (µM)	k cat, MVA (s−1)	k cat/K m, MVA (s−1 mM −1)
Methanococcoides burtonii	55 ± 11/331 ± 63	5 ± 0.1	90
Methanosarcina mazei	123 ± 9/511 ± 48	10 ± 0.1	81
Ramazzottius varieornatus	237 ± 68/4844 ± 1413	5 ± 0.8	21