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. Author manuscript; available in PMC: 2024 Mar 4.
Published in final edited form as: Curr Opin Struct Biol. 2023 Apr 13;80:102579. doi: 10.1016/j.sbi.2023.102579

FIGURE 2: Conformational equilibria involved in the early stages of α-Syn aggregation.

FIGURE 2:

Soluble α-Syn monomers contain a disordered N-terminus (depicted in blue) and a disordered C-terminus (depicted in red). The soluble state monomer ensemble contains various conformations. Specifically, there exist monomers that are in a conformation where the N- and C-terminal domains are close enough to interact with each other. It has been shown in vitro that monomers are in equilibria with a small population of dimers. NMR PRE experiments performed on the monomer-dimer equilibrium revealed the existence of weak transient, but highly specific interactions between N- and C- terminal domains in dimers. Interactions between the termini are shown in dashed lines.