Fig. 6.

Spatial Score. A Schematic describing the published SpatialScore metric of implied immunosuppressive or effector activity by the ratio of immune cell proximity relative to tumour distance. B A higher ratio was observed for macrophages in proximity with CD4⁺ cells relative to tumour cells in non-responsive patients. p = 0.002 C A higher ratio was observed for macrophages in proximity with CD8⁺ cells relative to tumour cells in non-responsive patients. p = 0.002 D The higher ratio for macrophages:CD4⁺ cells corresponded with poorer patient survival. E The higher ratio for macrophages:CD8⁺ cells corresponded with poorer patient survival. Not adjusted for multiple testing