Table 1.
Metabolomic perturbations in complex lipid pathways in a patient with RARS2-related mitochondrial disorder
| BIOCHEMICAL | Z-score | CATEGORY | HMDB_ID |
|---|---|---|---|
| 1-docosapentaenoyl-GPC (22:5n3) | 3.6 | Lysophospholipid | HMDB0010403 |
| 1-eicosapentaenoyl-GPC (20:5) | 3.2 | Lysophospholipid | HMDB0010397 |
| 1-stearoyl-GPI (18:0) | 2.0 | Lysophospholipid | HMDB0240261 |
| 1-dihomo-linolenoyl-GPC (20:3n3 or 6) | 2.0 | Lysophospholipid | HMDB0010394 |
| 1-docosahexaenoyl-GPC (22:6) | 2.3 | Lysophospholipid | HMDB0010404 |
| 1-stearoyl-2-oleoyl-GPC (18:0/18:1) | 2.0 | Phosphatidylcholine | HMDB0008038 |
| 1-oleoyl-2-dihomo-linolenoyl-GPC (18:1/20:3) | 1.9 | Phosphatidylcholine | HMDB0008113 |
| 1-stearoyl-2-docosapentaenoyl-GPC (18:0/22:5n3) | 3.9 | Phosphatidylcholine | HMDB0008056 |
| 1-palmitoyl-2-eicosapentaenoyl-GPC (16:0/20:5) | 3.3 | Phosphatidylcholine | HMDB0007984 |
| 1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6) | 3.1 | Phosphatidylcholine | HMDB0008047 |
| phosphatidylcholine (18:0/20:5, 16:0/22:5n6) | 2.8 | Phosphatidylcholine | HMDB0008050, HMDB0007989 |
| 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6) | 2.2 | Phosphatidylcholine | HMDB0008057 |
| 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6) | 2.2 | Phosphatidylcholine | HMDB0007991 |
| 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) | 2.6 | Phosphatidylethanolamine | HMDB0009012 |
| 1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6) | 2.2 | Phosphatidylethanolamine | HMDB0008946 |
| N-stearoyl-sphingosine (d18:1/18:0) | 2.4 | Ceramides | HMDB0004950 |
| palmitoyl dihydrosphingomyelin (d18:0/16:0) | 2.1 | Dihydrosphingomyelins | HMDB0010168 |
| sphingomyelin (d18:0/18:0, d19:0/17:0) | 2.0 | Dihydrosphingomyelins | HMDB0012087 |
| stearoyl sphingomyelin (d18:1/18:0) | 2.7 | Sphingomyelins | HMDB0001348 |
| palmitoyl sphingomyelin (d18:1/16:0) | 2.4 | Sphingomyelins | HMDB0010169 |
| sphingomyelin (d18:1/24:1, d18:2/24:0) | 2.2 | Sphingomyelins | HMDB0012107 |
| behenoyl sphingomyelin (d18:1/22:0) | 2.2 | Sphingomyelins | HMDB0012103 |
| lignoceroyl sphingomyelin (d18:1/24:0) | 2.1 | Sphingomyelins | HMDB0011697 |