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. 2022 Jun 2;2:871630. doi: 10.3389/fepid.2022.871630

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Copyright © 2022 van Os, Kanning, Wermer, Chavannes, Numans, Ruigrok, van Zwet, Putter, Steyerberg and Groenwold.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagram with three different operationalizations for the outcome definition. This Venn diagram shows the numbers of first-ever main adverse cardiovascular event cases resulting from the different outcome definitions: ICPC only (brown; 4,505 cases), ICPC and ATC codes for event-specific medication (clopidogrel, ticagrelor, and dipyridamole) including acetylsalicylic acid (red; 4,505 + 2,231 cases) and ICPC and ATC codes for event-specific medication, excluding acetylsalicylic acid (brown + green; 4,505 + 160 cases).