Table 2.

Research activities performed at each visit, and associated data collected for each Stage 1 and Stage 2 visit, during the AHHA Study.

Research activities at each visit and data derived as part of activity	Stage 1 (Baseline)	Stage 2 (6M−36M)	Time required (Minutes)
Informed consent and overview of study	X		45
Baseline questionnaire (self-administered, computer-assisted)	X		45
Demographics
Lifetime sexual history
Lifetime medical history (including HIV related med history)
Lifetime lifestyle history (smoking, alcohol, recreational drugs,
exercise)
Recent sexual history (past 6 months)
Recent lifestyle history (past 6 months)
Recent medical history (past 6 months)
The Fried Frailty Phenotype (FFP)*
Follow-up questionnaire (self-administered, computer-assisted)		X	30
Recent sexual history (past 6 months)
Recent lifestyle history (past 6 months)
Recent medical history (past 6 months)
The Fried Frailty Phenotype (FFP)*
Grip-strength test	X	X	15
The Fried Frailty Phenotype (FFP)*
15-foot timed walk test	X	X	15
The Fried Frailty Phenotype (FFP)*
Blood collection	X	X	15
Markers of inflammation (IL-6, CRP, D-dimer)
Veterans Aging Cohort Study (VACS) Index (PLWH)**
CD4+, HIV viral load (PLWH)
Anal clinical exam	X	X	45
Type specific anal HPV DNA
Histologically confirmed HSIL
Type specific anal HPV DNA
Total baseline time requirement			180
Total 6M−36M time requirement			120

6M−36M: 6 month to 36-month visits–occurring every 6 months, PLWH, participants living with HIV; IL-6, Interleukin-6; CRP, C-reactive protein.

^*The FFP is comprised of 5 domains, 3 are assessed by questionnaire, 1 by grip-strength test, and 1 by 15-foot timed walk test.

^**The VACS Index is comprised of CD4+ level, HIV-1 VL, hemoglobin, Aspartate Aminotransferase (AST) Alanine Aminotransferase (ALT), platelet count, creatinine level, HCV serostatus.